Which listed benzodiazepine has a half-life of 20 to 50 hours?

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Multiple Choice

Which listed benzodiazepine has a half-life of 20 to 50 hours?

Explanation:
Half-life determines how long a benzodiazepine stays active in the body and how much it can accumulate with repeated dosing. Diazepam is a long-acting benzodiazepine, with a typical half-life in the range of about 20 to 50 hours. Its effects are prolonged by active metabolites that linger after the parent drug is cleared, so the overall duration of action can extend over days. In contrast, the others listed have shorter durations: lorazepam generally has a half-life around 12 hours, triazolam about 2–5 hours, and midazolam roughly 1–4 hours. That’s why diazepam best matches the 20–50 hour range.

Half-life determines how long a benzodiazepine stays active in the body and how much it can accumulate with repeated dosing. Diazepam is a long-acting benzodiazepine, with a typical half-life in the range of about 20 to 50 hours. Its effects are prolonged by active metabolites that linger after the parent drug is cleared, so the overall duration of action can extend over days.

In contrast, the others listed have shorter durations: lorazepam generally has a half-life around 12 hours, triazolam about 2–5 hours, and midazolam roughly 1–4 hours. That’s why diazepam best matches the 20–50 hour range.

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